23P Vitamin D deficiency and SNPs in melatonin pathway genes potentiate breast cancer susceptibility: A pilot study

Previous studies have documented that both vitamin D deficiency and single nucleotide polymorphism (SNPs) of genes responsible for mediating downstream effects melatonin with development breast cancer. In India 70 percent the population suffers from Vitamin deficiency. There are no available reports on association SNPs in Melatonin towards cancer Indian population. To this end, we evaluated 50 D-deficient subjects studied gene expression patterns receptor (MTNR1a, MTNR1b) Arylalkylamine N-acetyltransferase (AANAT). Age matched patients without age normal (i.e served as control). demonstrated decreased MTNR1a, MTNR1b, AANAT deficient group compared to level (68% Vs 41%, p<0.001). Two two-staged analysis genome-wide (GWAS) showed MTNR1b progression metastasis group. Interestingly incidence was 32% more when other groups. Our pilot highlight fact products strong correlation its invasiveness. Significant increase related under conditions insufficiency leads us contention additive effect These experiments repeated using large sample size coupled animal knockout mice against background can shed light exact mechanism.